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Accepted: Published: Issue date: DOI:

The mechanism is straightforward: MC1R activation on melanocytes upregulates tyrosinase activity, driving conversion of tyrosine to eumelanin (the dark, photoprotective form of melanin)

doi:10.1016/j.cell.2009.07.049 Rizvi TA, Huang Y, Sidani A, Atit R, Largaespada DA, Boissy RE, Ratner N (2002) A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve